Q: I understand there are sophisticated, state-of-the-art human-biology based technologies available now and incredibly exciting – not to mention viable – for human patients: tell me more!!

The British Medical Journal highlights the failure of animal models to predict the responses of human patients in their Editor’s Choice, June 2014, titled How Predictive and Productive is Animal Research?

Dr Ray Greek speaks about personalized medicine and the life saving significance gene-based medical research and systems biology holds for treating disease in individual patients:

Visit Speaking of Human-Based Research, ready to help you with your discovery of up-to-the minute valid research methods, viable for patients and urgently in need of all the funding.

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Watch the Wyss Institute’s TED talk on personalized medicine and the potential of funding this instead of animal models – which still continue to receive the lion’s share of research funding despite pharma and the wider scientific community acknowledging lab animals fail human patients.

There are many valid research methods that are providing scientists the answers they need in the search for treatments and cures for human disease. Here are just a few:

In vitro (test tube) research on living tissue has been instrumental for many of the great discoveries that have advanced medicine. Though human tissue has not always been employed, it could have been because it has always been in ample supply. Blood, tissues, and organ cultures are ideal test-beds.

Epidemiology is the study of populations of humans to determine factors that could account for the prevalence of the disease within a population or for their disease immunity. Combined with genetic research and other nonanimal methods enumerated here, it provides very accurate information about whole systems.

Bacteria, viruses, and fungi reveal basic cellular and genetic properties.

Autopsy and cadavers are used for clarifying disease and teaching operating techniques such as fracture fixation, spine stabilization, ligament reconstruction, and other procedures. Physical models can be made for studying the wear on joints and other physiological matters of interest.

Genetic research has elucidated many genes that are responsible for specific diseases. Physicians can now ascertain their patients’ predisposition to certain diseases, which allows them to monitor individuals with greater focus and suggest optimal nutrition, lifestyle changes, and medications.

Clinical research on patients shows how humans respond to different treatments and determines whether or not one treatment is superior to another. We can attribute our fundamental knowledge of disease and hospital care to clinical research.

Post-marketing drug surveillance (PMDS) is the reporting process whereby every effect and side effect of a new medication is reported to a monitoring agency, such as the FDA. Despite its obvious benefits, PMDS is practiced rather erratically at the present time, as reporting methods are neither easy to implement nor enforced by the government. It is an underutilized opportunity that should be further explored.

Mathematical and computer modeling is a complex research method that employs mathematics to simulate living systems and chemical reactions.

Technology is largely responsible for the high standard of care we receive today. MRI scanners, CT scanners, PET scanners, X-rays, ultrasound, blood gas analysis machines, blood chemistry analysis machines, pulmonary artery catheters, arterial catheters, microscopes, monitoring devices, lasers, anesthesia machines and monitors, operating room equipment, computer based equipment, sutures, the heart-lung machine, pacemakers, electrocardiograms, electroencephalograms, bone and joint replacements, surgical staplers, laparoscopic surgery, the artificial kidney machine, and many more are examples of technological breakthroughs.

Today we also have stem cell research, gene-based medical research such as pharmacogenetics, toxicogenomics, systems biology, and other areas to study. Another important but oft-overlooked area of study is evolutionary biology. More emphasis needs to be placed on the study of evolution, the place of evolution in disease, and the implications of evolution for disease research and treatment.

When discussing animals as surrogates for humans in drug testing and disease research, society needs ways to test and conduct research that have a high predictive value for humans. We refer to these research methods and tests as predictive modalities. To call these predictive modalities alternatives is to misuse the word.

SUMMARY

Animal models are actually a very minor part of research. However, despite not allowing scientists to predict human response, they receive the lion’s share of the research funding. There are 2 points that need to be made:

1. Society does not need new research methods it simply needs to fund the ones we already have. For example, performing research on animals is not going to solve the problem of drug resistant infections. Research in physics on the other hand might because physics offers society the chance to design nanomachines that will mechanically destroy the bacteria. Regardless of the bacteria’s genetic makeup it can be mechanically crushed or chewed up. So society needs the knowledge that would come from underfunded research areas like physics, chemistry, genetics, epidemiology, clinical research and so forth.

      1. 2. Society needs to make a fundamental change from animal-based research to human-based research. If it is humans we are trying to help then scientists must study diseases and drug reactions in humans. This is already being done but again funding needs to be increased to these areas. The way to accomplish both number 1 and 2 is to stop funding research that does not work, thus freeing up the money that needs to be spent on the research where future cures will come from!

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